制药科学理学学士荣誉学士

课程模块Modules

• 年一Year one
• 年二Year two
• Year three

6 modules

• principles of aqueous and non-aqueous dispersed systems, suspensions and emulsions
• formulation effects following major routes of drug administration
• physiological barriers to absorption and mechanisms of drug transport
• basic concepts of pharmacokinetics — absorption, distribution, metabolism and excretion (ADME)
• quantitative concepts such as half-life, clearance and volume of distribution
• experimental and calculation-based approaches used to evaluate bioavailability
• biochemical foundations and the molecules of life
• 遗传基础与流动遗传信息genetic foundations and the flow of genetic information
• 细胞基础cellular foundations
• 导论生理学与方向心血管系统与血液学an introduction to physiology with a focus on the cardiovascular system and haematology
• the principles of drug action; receptor-drug interactions
• drug structure and bonding
• valency, orbitals, electronic configurations and bond types
• conjugation, aromaticity, resonance and their relevance to acid/base chemistry
• nomenclature, functional groups
• stereochemistry
• an introduction to spectroscopy
• an introduction to the human endocrine system and the body’s metabolic processes
• hormonal control of metabolism
• an introduction to common endocrine and metabolic diseases and their treatments
• C-heteroatom bond formation reactions, including C-N, C-halogen, C-O and C-S bond-forming reactions
• structure determination of drug molecules, including spectroscopic techniques (NMR, IR, MS) and chromatography methods
• C-C bond formation reactions, including organometallic reactions, enol and enolate chemistry
• electrophilic and nucleophilic aromatic substitution reactions
• a foundation on the principles that underlie the processing and manufacture of solid dosage forms
• an understanding of the material science and physical chemistry of pharmaceutical powders
• formulation and production of solid dosage forms (tablets and inhalation formulations)
• novel materials for pharmaceutical formulations, including polymers and nanomaterials
• bioelectronic and responsive delivery systems
• controlled-release and long-acting injectable formulations
• physiological and cellular barriers influencing absorption and distribution
• drug-targeting approaches such as polymer–drug conjugates, antibody–drug conjugates and stealth nanoparticles
• integration of formulation design with biological and clinical requirements
• use of digital tools for formulation design, data analysis and presentation
• key concepts in modern drug discovery, including foundations and terminology
• molecular recognition; structure-activity relationships (SARs)
• structure- and ligand-based design
• ADME/DMPK and physicochemical optimisation
• 计算与生物物理方法使用药物设计computational and biophysical methods used in drug design
• an introduction in microbiology, covering bacteria and viruses
• antibiotics and non-antibiotic antimicrobials and their use
• an introduction to the cells, molecules and diseases of the human immune system
• an introduction to recombinant DNA technology and prokaryotic and viral gene regulation
• an introduction to signal transduction networks using examples related to oncology
• 导论过程细胞分部an introduction to the process of cell division
• an introduction to the Hallmarks of Cancer
• pharmacology of cytotoxic and molecularly targeted chemotherapy
• manufacture of biotechnology products, from cell culture and purification to formulation
• protein and nucleic-acid therapeutics, including monoclonal antibodies and RNA technologies
• formulation and delivery approaches for macromolecular therapeutics
• physiological and immunological barriers to biologic delivery
• 实验室方法生产生物制药laboratory methods for production of biopharmaceuticals
• strategies for total and semi-chemical synthesis
• aromatic, heterocyclic, macrocyclic, peptide and oligonucleotide drugs with increasing structural complexity
• the synthesis of diverse chemical analogues for structure-activity relationship assessments

4 modules

• advances in protein and antibody technologies
• new biological entities, including RNA and cell-based therapeutics
• 进展基因治疗含基因组编辑技术advances in gene therapy, including genome-editing techniques
• 制剂生物产品formulation of biological products
• industry and patient views of biological products
• an opportunity to undertake an original research study
• the opportunity to use state-of-the-art instrumentation available in the School of Pharmacy
• This module covers
• an overview of the pharmaceutical industry and the process of discovery and development of pharmaceutical products
• principles relevant to manufacturing methods and quality assurance processes
• pharmaceutical regulations and guidelines, including quality-by-design
• principles relevant to manufacturing, including sustainability and life-cycle assessment
• 制剂与发展生物制药产品formulation and development of biopharmaceutical products
• development of standard operating procedures in the laboratory
• 传统药物含传统中文药物印度药物与非洲药物traditional medicines, including traditional Chinese medicines, Indian medicines and African medicines
• the use of nutritional supplements, including vitamins, minerals, trace elements
• data structures: lists and tuples, dictionaries and sets
• flow control: loops, conditional statements, errors and exceptions
• program organisation: packages, libraries and modules
• data manipulation with Numpy
• graph drawing with Matplotlib
• chemical data manipulation with RDKit